Scientists at St. Jude Children's Research Hospital discovered how MYC oncogene expression is controlled in pediatric medulloblastoma tumors through extrachromosomal DNA.
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An enhancer within tumors provides a potential target for 'undruggable' MYC in pediatric medulloblastoma
MYC-Amplified Group 3 Medulloblastoma (G3-MB) Cancer type targeted
Extrachromosomal DNA (EcDNA) Amplification Key discovery mechanism
Key Enhancer Within Tumors Therapeutic target identified
St. Jude Children'S Research Hospital Research location