Researchers in Brazil have solved a two-decade mystery about why p53, the 'guardian of the genome' that suppresses tumors, is paradoxically the most frequently mutated protein in human cancers.
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Cracking the code of p53 fragility: Why the genome guardian is prone to failure

Functional Flexibility Vs Structural Fragility trade-off Protein flexibility
Water Penetrates Protein Core Instability mechanism
4 Brazilian Universities Research institutions
20+ years Study duration
20+ Years research duration
4 Institutions researchers involved