Researchers engineered nanoparticles that overcome multidrug-resistant cancer by first disabling the cancer cell's drug-expulsion mechanism before releasing anticancer drugs.
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Nanoparticles overcome drug-resistant cancer via sequential drug release and photothermal therapy

Multidrug Resistance (MDR) In Cancer Cells Problem addressed
Sequential Disabling Of Drug-Expulsion, Then Drug Release Novel mechanism
Journal Of Controlled Release Publication venue