A single dose of psilocybin causes measurable anatomical brain changes lasting up to a month, according to research from UC San Francisco and Imperial College London.
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One dose of psilocybin changes the human brain, leading to higher entropy

Up To 1 Month time Duration of brain changes
Psilocybin psychedelic agent Compound studied
Higher Brain Entropy Observed neurological metric Research finding
2 Leading Research Centers institutions involved